3 weeks ago, AMD took an unusually proactive step of reaching out to individual Redditors who were experiencing USB connectivity problems on Ryzen systems using 500 series motherboards. Users of VR headsets seem to have been especially plagued by these issues, judging by the comments on /r/AMD.
It appears this campaign to collect relevant information from Redditors was successful. Today AMD announced that a future AGESA update 220.127.116.11, which is expected in April, will resolve these problems.
We would like to thank the community here on /r/AMD for its assistance with logs and reports as we investigated the intermittent USB connectivity you highlighted. With your help, we believe we have isolated the root cause and developed a solution that addresses a range of reported symptoms, including (but not limited to): USB port dropout, USB 2.0 audio crackling (e.g. DAC/AMP combos), and USB/PCIe Gen 4 exclusion.
AMD has prepared AGESA 18.104.22.168 to deploy this update, and we plan to distribute 22.214.171.124 to our motherboard partners for integration in about a week. Customers can expect downloadable BIOSes containing AGESA 126.96.36.199 to begin with beta updates in early April.